In addition to teaching, CoCIS staff and students through their research groups conduct cutting edge research and have come up with products and services that have impacted on livelihoods in deferent sectors of agriculture, health, education, industry and business. Main research areas software and enterprise engineering, development informatics, artificial intelligence, networks and systems security, ICT for Education, mobile computing and communication, documentary heritage, records management, information policy and publishing, knowledge management and ICTs for Libraries.

The college has about 30 running projects including AirQO, Life Health Uganda, Internationalization in Library and Information Science Education, Pathways to Change towards Gender justice in STEM Research In Africa (GeJuSTA), ICT Platform for Pathogen Econony, Predicting Sweet potato sensory Attribution Using Image Analysis, Using Machine Learning for Localised and Targeted Agricultural Advisory to small holder farmers in Uganda, Next Generation Cassava II, Building Luganda Automatic Speech Recognition Models for Agriculture(Google NLP), Drone –Based Agricultural Dataset for Crop Yield Estimation, Helmet Labeling Crops, Lacuna Malaria Datasets, Using health information technology governance and epidemiologic approaches to implement sustainable digital health systems in central Uganda (PIRA), Adaptive Environment Monitoring Network for East Africa- AdeMNEA and The F.A.T.E of AI African Agriculture, Mobile ELISA and Syndromic Datasets.